Dipeptide Diaminobutyroyl Benzylamide Diacetate Middel Peptide Anti-aging Dipeptide Diaminobutyroyl Benzylamide Diacetate at a glance Considered a neurotransmitter-inhibiting peptide Also goes by the tradename SYN®-AKE Touted as mimicking the activity of snake venom to paralyze muscles that induce wrinkles More independent studies are needed to validate potential benefits Dipeptide Diaminobutyroyl Benzylamide Diacetate description Dipeptide diaminobutyroyl benzylamide diacetate is considered a neurotransmitter-inhibiting peptide, meaning it could have the ability to target expression lines. It also goes by the tradename SYN®-AKE, which nods to the manufacturer’s origin stories of its ability to “mimic the activity of snake venom toxin Waglerin 1.” This is extolled to paralyze muscle contraction related to wrinkles, similar to what injectable procedures can offer—however, it’s important to note that these claims are overexaggerated. While the research regarding dipeptide diaminobutyroyl benzylamide diacetate is alluring, the issue is that these studies are tied back to companies with a financial interest in profiting from this ingredient, so we don’t have reliable independent research to go by at the time of this writing. Is there potential for this ingredient to help minimize expression lines? Possibly, but further independent studies are necessary to validate these findings. Suppliers of dipeptide diaminobutyroyl benzylamide diacetate note that it comes as a white powder in its raw material form. Manufacturers also classify this ingredient as a skin-conditioning agent. Usage levels range from 0.005%–1%. Related ingredients: Peptides